Mast cell production and response to IL-4 and IL-13

Function in Mice Deficient in IL-4 and IL-13 IgE Generation and Mast Cell Effector

Intestinal Epithelial Cell Function IL-13-Induced Alterations in Murine Role of STAT6 and Mast Cells in IL-4- and

Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function.

Gastrointestinal nematode infections generally invoke a type 2 cytokine response, characterized by the production of IL-4, IL-5, IL-9, and IL-13. Among these cytokines, IL-4 and IL-13 exhibit a functional overlap that can be explained by the sharing of a common receptor or receptor component (IL-4Ralpha). Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiate...

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15

Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce pe...

association of the expression of il-4 and il-13 genes, il-4 and ige serum levels with allergic asthma

immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...